The renaturation of deoxyribonucleic acids. I. Rates of bimolecular reactions of complementary and noncomplementary Gaussian chains
Identifieur interne : 005262 ( Main/Exploration ); précédent : 005261; suivant : 005263The renaturation of deoxyribonucleic acids. I. Rates of bimolecular reactions of complementary and noncomplementary Gaussian chains
Auteurs : Akiyoshi Wada [Japon] ; Hiroko Yamagami [Japon]Source :
- Biopolymers [ 0006-3525 ] ; 1964-10.
Abstract
The mechanism of the renaturation of DNA molecules is examined on the basis of the bimolecular interaction of Gaussian chain polymers. In the nucleus formation by hydrogen bonding in segment–segment interaction, two types of interchain interaction, that is, one between complementary chains and one between noncomplementary chains, and one noncomplementary intrachain interaction are considered to be, in competition. Several previously observed characteristics of the renaturation process are displayed by this simple model. In particular it accounts for the dependence of the extent of renaturation on the heterogeneity, molecular weight, and radius of gyration of DNA, and of the ratios of the reaction rates between complementary and noncomplementary segments. Among these variables the ratio of reaction rates has shown to have a quite specific value, as high as the order of 104, which favors the complementary‐strand interaction. This very great bias in favor of complementary strand interaction emphasizes that the renaturation phenomena displays the same character of biological specificity that is associated with enzyme–substrate interaction or antigen–antibody interaction. Moreover, since DNA is a good example of a one‐dimensional system, it seems to provide a suitable clue for pursuing the analysis of pattern recognition at the macromolecular level.
Url:
DOI: 10.1002/bip.1964.360020504
Affiliations:
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Rates of bimolecular reactions of complementary and noncomplementary Gaussian chains</title><author><name sortKey="Wada, Akiyoshi" sort="Wada, Akiyoshi" uniqKey="Wada A" first="Akiyoshi" last="Wada">Akiyoshi Wada</name><affiliation wicri:level="3"><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><wicri:orgArea>Department of Physics, Faculty of Science, The University of Tokyo, Bunkyo‐ku</wicri:orgArea></affiliation></author><author><name sortKey="Yamagami, Hiroko" sort="Yamagami, Hiroko" uniqKey="Yamagami H" first="Hiroko" last="Yamagami">Hiroko Yamagami</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>National Institute of Radiological Science, Kurosuna, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Biopolymers</title><title level="j" type="alt">BIOPOLYMERS</title><idno type="ISSN">0006-3525</idno><idno type="eISSN">1097-0282</idno><imprint><biblScope unit="vol">2</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="445">445</biblScope><biblScope unit="page" to="462">462</biblScope><biblScope unit="page-count">18</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1964-10">1964-10</date></imprint><idno type="ISSN">0006-3525</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-3525</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mechanism of the renaturation of DNA molecules is examined on the basis of the bimolecular interaction of Gaussian chain polymers. In the nucleus formation by hydrogen bonding in segment–segment interaction, two types of interchain interaction, that is, one between complementary chains and one between noncomplementary chains, and one noncomplementary intrachain interaction are considered to be, in competition. Several previously observed characteristics of the renaturation process are displayed by this simple model. In particular it accounts for the dependence of the extent of renaturation on the heterogeneity, molecular weight, and radius of gyration of DNA, and of the ratios of the reaction rates between complementary and noncomplementary segments. Among these variables the ratio of reaction rates has shown to have a quite specific value, as high as the order of 104, which favors the complementary‐strand interaction. This very great bias in favor of complementary strand interaction emphasizes that the renaturation phenomena displays the same character of biological specificity that is associated with enzyme–substrate interaction or antigen–antibody interaction. Moreover, since DNA is a good example of a one‐dimensional system, it seems to provide a suitable clue for pursuing the analysis of pattern recognition at the macromolecular level.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Wada, Akiyoshi" sort="Wada, Akiyoshi" uniqKey="Wada A" first="Akiyoshi" last="Wada">Akiyoshi Wada</name></region><name sortKey="Yamagami, Hiroko" sort="Yamagami, Hiroko" uniqKey="Yamagami H" first="Hiroko" last="Yamagami">Hiroko Yamagami</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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